Difference between revisions of "HtpG"

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|style="background:#ABCDEF;" align="center"|'''Function''' || chaperone
 
|style="background:#ABCDEF;" align="center"|'''Function''' || chaperone
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU39820 htpG]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU39820 htpG]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[csbC]]'', ''[[yxcA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[csbC]]'', ''[[yxcA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB16018&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU39820 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU39820 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU39820 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:htpG_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:htpG_context.gif]]

Revision as of 14:17, 13 May 2013

  • Description: class III heat-shock protein (molecular chaperone)

Gene name htpG
Synonyms yxbB
Essential no
Product class III heat-shock protein (molecular chaperone)
Function chaperone
Gene expression levels in SubtiExpress: htpG
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 72 kDa, 4.668
Gene length, protein length 1878 bp, 626 aa
Immediate neighbours csbC, yxcA
Sequences Protein DNA Advanced_DNA
Genetic context
HtpG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HtpG expression.png




























Categories containing this gene/protein

chaperones/ protein folding, heat shock proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU39820

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: heat shock protein 90 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2IOQ (from Escherichia coli, 39% identity, 61% similarity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by high temperature PubMed
  • Regulatory mechanism: unknown
  • Additional information:

Biological materials

  • Mutant: GP1159 (del cat) available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Wolfgang Schumann, Bayreuth University, Germany Homepage

Your additional remarks

References

Saskia Versteeg, Angelika Escher, Andy Wende, Thomas Wiegert, Wolfgang Schumann
Regulation of the Bacillus subtilis heat shock gene htpG is under positive control.
J Bacteriol: 2003, 185(2);466-74
[PubMed:12511492] [WorldCat.org] [DOI] (P p)

S Versteeg, A Mogk, W Schumann
The Bacillus subtilis htpG gene is not involved in thermal stress management.
Mol Gen Genet: 1999, 261(3);582-8
[PubMed:10323241] [WorldCat.org] [DOI] (P p)

A Schulz, S Schwab, G Homuth, S Versteeg, W Schumann
The htpG gene of Bacillus subtilis belongs to class III heat shock genes and is under negative control.
J Bacteriol: 1997, 179(10);3103-9
[PubMed:9150201] [WorldCat.org] [DOI] (P p)