HprT

From SubtiWiki
Revision as of 14:58, 11 November 2013 by 134.76.70.252 (talk)
Jump to: navigation, search
  • Description: trigger enzyme,hypoxanthine phosphoribosyltransferase and part of a transcription activator

Gene name hprT
Synonyms
Essential yes PubMed
Product hypoxanthine phosphoribosyltransferase
Function purine salvage and interconversion, control of ftsH expression
Gene expression levels in SubtiExpress: hprT
Interactions involving this protein in SubtInteract: HprT
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine synthesis, Nucleotides (regulation)
MW, pI 20 kDa, 4.603
Gene length, protein length 540 bp, 180 aa
Immediate neighbours tilS, ftsH
Sequences Protein DNA DNA_with_flanks
Genetic context
HprT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HprT expression.png















Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, transcription factors and their control, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes

This gene is a member of the following regulons

SigM regulon

The TilS-HprT regulon

The gene

Basic information

  • Locus tag: BSU00680

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´PubMed

Database entries

  • Structure: 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References