Difference between revisions of "HprT"

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(Database entries)
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}},
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{{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, W, X, Y)]]}},
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{{SubtiWiki category|[[essential genes]]}}
 
=The protein=
 
=The protein=
  

Revision as of 17:20, 30 November 2010

  • Description: hypoxanthine phosphoribosyltransferase

Gene name hprT
Synonyms
Essential yes PubMed
Product hypoxanthine phosphoribosyltransferase
Function purine salvage and interconversion
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine synthesis, Nucleotides (regulation)
MW, pI 20 kDa, 4.603
Gene length, protein length 540 bp, 180 aa
Immediate neighbours tilS, ftsH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HprT context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU00680

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, cell envelope stress proteins (controlled by SigM, W, X, Y), essential genes

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 1J7J (from Salmonella typhimurium, 51% identity, 73% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References