hom

hom
168

homoserine dehydrogenase (NADPH)

locus
BSU_32260
Molecular weight
47.33 kDa
pI
4.9
Protein length
Gene length
function
biosynthesis of methionine and threonine
product
homoserine dehydrogenase (NADPH)
essential
no
ec
1.1.1.3
synonyms
hom

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0460 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,314,828 3,316,129
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The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + NAD(P)H+H+ --> L-homoserine + NAD(P)+ [pubmed|6786715]
Protein family
Homoserine dehydrogenase family (single member, according to UniProt)
[wiki|Domains]
[wiki|ACT domain] (aa 350-426) (according to UniProt)
[wiki|Cofactors]
NADPH [pubmed|6786715]
Structure
[PDB|2EJW] (from ''Thermus thermophilus hb8'', 37% identity, 57% similarity)
[AF|P19582]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|0F40291BB10DB6D7DFD94B9C7D700F4410C4EE69|yutH]-[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]-[gene|4A839F8A53DF75DF01FE410EBD3361759C3B1C86|thrC]-[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]
description
[Pubmed|22383849]
regulation
expressed during [wiki|sporulation] [Pubmed|22383849]
Open in new tab

[gene|0F40291BB10DB6D7DFD94B9C7D700F4410C4EE69|yutH]→[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]

2024-03-10 09:01:53

Jstuelk

78

679308b32ee019040de1f3917a024913a4a6e24e

A05F487B4319B2D895BE22D03C7D331712EA7165

genes
[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]-[gene|4A839F8A53DF75DF01FE410EBD3361759C3B1C86|thrC]-[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]
description
[Pubmed|12107147]
regulation
expressed in the presence of lysine or cysteine ([wiki|ThrR]) [Pubmed|27260660]
regulatory mechanism
[protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]: repression, [Pubmed|24163341], in [regulon|protein:90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY regulon]
[protein|857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA]: repression, [Pubmed|25755103], in [regulon|protein:857EF1AC54DEA0690C01B7F8CEFFD16312C58F20|tnrA regulon]
[protein|A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR]: repression, [Pubmed|27260660], in [regulon|protein:A4B7CF7A1C704C750AFAD97A43AF975260935083|thrR regulon]
Open in new tab

[gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]→[gene|290302BA8A4E44C62AE3071C1F7DE18B20605607|thrB]

2024-03-10 09:02:04

ghost

78

222d0d37f0abf96a1c1d52c80944e1ea90292f91

CF7B5B8FEE827A7467051420FCA74276BC912664

Biological materials
Mutant
BKE32260 ([gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAAAAACTCCACCTTTCT, downstream forward: _UP4_GTAGAAGGGAACGGTTGGAG
BKK32260 ([gene|11421D5BD3AB6C205DDA0864F878E2B04340033F|hom]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32260 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAAAAACTCCACCTTTCT, downstream forward: _UP4_GTAGAAGGGAACGGTTGGAG
lacZ fusion
pBP312 (in [wiki|pAC5]), available in [wiki|Fabian Commichau]'s lab [Pubmed|27260660]
References
12107147,18763711,3139660,19258532,24163341,25777134,15378759,25755103,27260660,6786715,33046675

11421D5BD3AB6C205DDA0864F878E2B04340033F

Page visits: 4221

Time of last update: 2024-03-28 02:31:20

Author of last update: Jstuelk