HisJ

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  • Description: histidinol phosphate phosphatase

Gene name hisJ
Synonyms ytvP
Essential no
Product histidinol phosphate phosphatase
Function biosynthesis of histidine
Gene expression levels in SubtiExpress: hisJ
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 30 kDa, 5.061
Gene length, protein length 804 bp, 268 aa
Immediate neighbours ezrA, refZ
Sequences Protein DNA DNA_with_flanks
Genetic context
HisJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HisJ expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29620

Phenotypes of a mutant

auxotroph for histidine

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-histidinol phosphate + H2O = L-histidinol + phosphate (according to Swiss-Prot)
  • Protein family: HisK subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France

Your additional remarks

References

D le Coq, S Fillinger, S Aymerich
Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis.
J Bacteriol: 1999, 181(10);3277-80
[PubMed:10322033] [WorldCat.org] [DOI] (P p)