HisI

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  • Description: phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase

Gene name hisI
Synonyms hisIE
Essential no
Product phosphoribosyl-AMP cyclohydrolase /
phosphoribosyl-ATP pyrophosphohydrolase
Function biosynthesis of histidine
Gene expression levels in SubtiExpress: hisI
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 23 kDa, 4.627
Gene length, protein length 627 bp, 209 aa
Immediate neighbours yvcA, hisF
Sequences Protein DNA DNA_with_flanks
Genetic context
HisI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HisI expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU34860

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References