Difference between revisions of "HisI"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of histidine
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of histidine
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU34860 hisI]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU34860 hisI]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/histidine.html His]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/histidine.html His]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvcA]]'', ''[[hisF]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yvcA]]'', ''[[hisF]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15491&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU34860 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU34860 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU34860 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:hisI_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:hisI_context.gif]]

Revision as of 13:56, 13 May 2013

  • Description: phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase

Gene name hisI
Synonyms hisIE
Essential no
Product phosphoribosyl-AMP cyclohydrolase /
phosphoribosyl-ATP pyrophosphohydrolase
Function biosynthesis of histidine
Gene expression levels in SubtiExpress: hisI
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 23 kDa, 4.627
Gene length, protein length 627 bp, 209 aa
Immediate neighbours yvcA, hisF
Sequences Protein DNA Advanced_DNA
Genetic context
HisI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HisI expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU34860

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)