hisG

168

ATP phosphoribosyltransferase

locus: BSU_34920

Molecular weight: 23.47 kDa

pI: 4.53

Protein length: 213 aa

Gene length: 642 bp

function: biosynthesis of histidine

product: ATP phosphoribosyltransferase

essential: no

ec: 2.4.2.17

synonyms: hisG

List of homologs in different organisms, belongs to COG0040 (Galperin et al., 2021)

Gene

Coordinates: 3,587,551  3,588,192

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The protein

Catalyzed reaction/ biological activity

• 1-(5-phospho-β-D-ribosyl)-ATP + diphosphate --> 5-phospho-α-D-ribose 1-diphosphate + ATP (according to UniProt)

Protein family

• ATP phosphoribosyltransferase family (single member, according to UniProt)

Structure

• [PDB|2VD2]
• [AF|O34520]

[wiki|Localization]

• cytoplasm (according to Swiss-Prot)

Biological materials

Mutant

• GP3621 (Δ[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]::''aphA3''), available in [wiki|Jörg Stülke]'s lab
• GP3624 (Δ[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]::''phleo''), available in [wiki|Jörg Stülke]'s lab
• BKE34920 ([gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34920 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA,  downstream forward: _UP4_GTTGTGGAAGGAGAGACGGC
• BKK34920 ([gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34920 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA,  downstream forward: _UP4_GTTGTGGAAGGAGAGACGGC

References

• 12107147,28516784