HisF

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  • Description: cyclase-like protein

Gene name hisF
Synonyms
Essential no
Product cyclase-like protein
Function biosynthesis of histidine
Gene expression levels in SubtiExpress: hisF
Metabolic function and regulation of this protein in SubtiPathways:
hisF
MW, pI 27 kDa, 5.238
Gene length, protein length 756 bp, 252 aa
Immediate neighbours hisI, hisA
Sequences Protein DNA DNA_with_flanks
Genetic context
HisF context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HisF expression.png















Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, most abundant proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU34870

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O (according to Swiss-Prot)
  • Protein family: hisA/hisF family (according to Swiss-Prot)
  • Paralogous protein(s): HisA

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References