HisB

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  • Description: imidazoleglycerol-phosphate dehydratase

Gene name hisB
Synonyms
Essential no
Product imidazoleglycerol-phosphate dehydratase
Function biosynthesis of histidine
Gene expression levels in SubtiExpress: hisB
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 21 kDa, 5.598
Gene length, protein length 582 bp, 194 aa
Immediate neighbours hisH, hisD
Sequences Protein DNA DNA_with_flanks
Genetic context
HisB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
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Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU34900

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O (according to Swiss-Prot)
  • Protein family: imidazoleglycerol-phosphate dehydratase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2AE8 (from Staphylococcus aureus subsp. aureus n315 mutant, 48% identity, 65% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)