hisA

hisA
168

phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF

locus
BSU_34880
Molecular weight
26.38 kDa
pI
4.84
Protein length
Gene length
function
biosynthesis of histidine
product
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF
essential
no
ec
5.3.1.16
synonyms
hisA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0106 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,584,317  3,585,054
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The protein
Catalyzed reaction/ biological activity
1-(5-phospho-β-D-ribosyl)-5-[(5-phospho-β-D-ribosylamino)methylideneamino]imidazole-4-carboxamide --> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide (according to UniProt)
Protein family
HisA/HisF family (with [protein|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF], according to UniProt)
Structure
[PDB|2VEP] (from ''Streptomyces coelicolor'', 41% identity, 58% similarity) [Pubmed|17967415]
[AF|O35006]
Paralogous protein(s)
[protein|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
description
[Pubmed|12107147]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM] [pubmed|30355672]
regulatory mechanism
[protein|F4097349A563503468A2A14F062AEAC532C7917A|rnpM]: unknown, [pubmed|30355672], in [regulon|protein:F4097349A563503468A2A14F062AEAC532C7917A|rnpM regulon]
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[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]→[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]

2024-03-26 19:01:51

Jstuelk

75

896e17f5309df81d9427f38fec175515ad428723

B6AAF7601668444EDDC2FE084A87885740B98ACD

Biological materials
Mutant
1A626 ( ''hisA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A626&Search=1A626 BGSC]
BKE34880 ([gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34880 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCCGGATATAATGTAAAAG,  downstream forward: _UP4_GCGCTTGAAAGGGTGAAGCG
BKK34880 ([gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34880 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TGCCGGATATAATGTAAAAG,  downstream forward: _UP4_GCGCTTGAAAGGGTGAAGCG
References
12107147

148F0C7983250F50676D234DB713E532AA55DDBF

Page visits: 2022

Time of last update: 2024-03-28 14:56:53

Author of last update: Melvin.boenninger