HepS

• Description: heptaprenyl diphosphate synthase component I
  
  

Gene name	hepS
Synonyms	gerCA, hepA
Essential	yes PubMed
Product	heptaprenyl diphosphate synthase component I
Function	menaquinone biosynthesis
Gene expression levels in SubtiExpress: hepS
MW, pI	28 kDa, 6.273
Gene length, protein length	753 bp, 251 aa
Immediate neighbours	menH, mtrB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors, essential genes

The gene

Basic information

• Locus tag: BSU22760

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU22760

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: All-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate (according to Swiss-Prot)

• Protein family: Methylisocitrate lyase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU22760

• Structure:

• UniProt: P31112

• KEGG entry: [2]

• E.C. number: 2.5.1.30

Expression and regulation

• Operon:

• Expression browser: hepS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 358 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 958 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Becky M Hess, Junfeng Xue, Lye Meng Markillie, Ronald C Taylor, H Steven Wiley, Birgitte K Ahring, Bryan Linggi
Coregulation of Terpenoid Pathway Genes and Prediction of Isoprene Production in Bacillus subtilis Using Transcriptomics.
PLoS One: 2013, 8(6);e66104
[PubMed:23840410] [WorldCat.org] [DOI] (I e)