HemE

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  • Description: uroporphyrinogen decarboxylase (uroporphyrinogen III)

Gene name hemE
Synonyms
Essential no
Product uroporphyrinogen decarboxylase (uroporphyrinogen III)
Function heme biosynthesis
Gene expression levels in SubtiExpress: hemE
MW, pI 39 kDa, 5.262
Gene length, protein length 1059 bp, 353 aa
Immediate neighbours pbpF, hemH
Sequences Protein DNA DNA_with_flanks
Genetic context
HemE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HemE expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU10120

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Uroporphyrinogen III = coproporphyrinogen + 4 CO2 (according to Swiss-Prot)
  • Protein family: uroporphyrinogen decarboxylase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jun Fan, Qun Liu, Quan Hao, Maikun Teng, Liwen Niu
Crystal structure of uroporphyrinogen decarboxylase from Bacillus subtilis.
J Bacteriol: 2007, 189(9);3573-80
[PubMed:17122346] [WorldCat.org] [DOI] (P p)

M Hansson, L Hederstedt
Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.
J Bacteriol: 1992, 174(24);8081-93
[PubMed:1459957] [WorldCat.org] [DOI] (P p)