HemE

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Gene name hemE
Synonyms
Essential no
Product uroporphyrinogen decarboxylase (uroporphyrinogen III)
Function heme biosynthesis
Gene expression levels in SubtiExpress: hemE
MW, pI 39 kDa, 5.262
Gene length, protein length 1059 bp, 353 aa
Immediate neighbours pbpF, hemH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HemE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HemE expression.png
























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU10120

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Uroporphyrinogen III = coproporphyrinogen + 4 CO2 (according to Swiss-Prot)
  • Protein family: uroporphyrinogen decarboxylase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

M Hansson, L Hederstedt
Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes.
J Bacteriol: 1992, 174(24);8081-93
[PubMed:1459957] [WorldCat.org] [DOI] (P p)