GtaB

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  • Description: UTP-glucose-1-phosphate uridylyltransferase, general stress protein

Gene name gtaB
Synonyms
Essential no
Product UTP-glucose-1-phosphate uridylyltransferase
Function biosynthesis of teichoic acid
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 32 kDa, 4.913
Gene length, protein length 876 bp, 292 aa
Immediate neighbours mnaA, ggaB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GtaB context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, biosynthesis of cell wall components, general stress proteins (controlled by SigB), phosphoproteins

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU35670

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose (according to Swiss-Prot)
  • Protein family: UDPGP type 2 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2E3D (from E. coli, 44% identity, 61% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Alain Lévine, Françoise Vannier, Cédric Absalon, Lauriane Kuhn, Peter Jackson, Elaine Scrivener, Valérie Labas, Joëlle Vinh, Patrick Courtney, Jérôme Garin, Simone J Séror
Analysis of the dynamic Bacillus subtilis Ser/Thr/Tyr phosphoproteome implicated in a wide variety of cellular processes.
Proteomics: 2006, 6(7);2157-73
[PubMed:16493705] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)

D Varón, S A Boylan, K Okamoto, C W Price
Bacillus subtilis gtaB encodes UDP-glucose pyrophosphorylase and is controlled by stationary-phase transcription factor sigma B.
J Bacteriol: 1993, 175(13);3964-71
[PubMed:8320212] [WorldCat.org] [DOI] (P p)

H M Pooley, D Paschoud, D Karamata
The gtaB marker in Bacillus subtilis 168 is associated with a deficiency in UDPglucose pyrophosphorylase.
J Gen Microbiol: 1987, 133(12);3481-93
[PubMed:2846750] [WorldCat.org] [DOI] (P p)