glxB

glxB
168

glyoxalase II

locus
BSU_32660
Molecular weight
14.30 kDa
pI
4.61
Protein length
Gene length
function
detoxification of methylglyoxal
product
glyoxalase II
essential
no
synonyms
glxB, yurT

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0346 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,354,551  3,354,934
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The protein
Catalyzed reaction/ biological activity
S-lactoyl-bacillithiol (BSH)  - D-lactate + BSH [Pubmed|24330391]
Protein family
glyoxalase I family (with [protein|54E05955FF1732F434A0FAB08967573B8DD3ADD2|glxA] and [protein|F02D4AFF60ADDDC5F5B85A3ACCA3AF803560B91E|yraH], according to UniProt)
[wiki|Domains]
[wiki|VOC domain] (aa 1-127) (according to UniProt)
Structure
[PDB|4G6X] (from Catenulispora acidiphila, 53% identity)
[AF|O32161]
Expression and Regulation
Operons
genes
[gene|85E5D3211F27DA64C4E829385C6A08F4A4A2F874|yuzN]-[gene|0A244A61A9A484F0BF083C918AE5A2C6A3F8157E|glxB]
description
[Pubmed|22383849]
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[gene|85E5D3211F27DA64C4E829385C6A08F4A4A2F874|yuzN]→[gene|0A244A61A9A484F0BF083C918AE5A2C6A3F8157E|glxB]

2024-02-28 14:51:03

Jstuelk

45

edcf997816bbd4be69d4f17c512a7580bf6f6ec8

A70305D599B25F366E31E41F6728D032F1F07520

Biological materials
Mutant
MGNA-B582 (yurT::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1581 NBRP B. subtilis, Japan]
BKE32660 ([gene|0A244A61A9A484F0BF083C918AE5A2C6A3F8157E|glxB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE32660 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATACTGTTTTTCCCTCCTT,  downstream forward: _UP4_TAACCGATTCAGTCGCGTCC
BKK32660 ([gene|0A244A61A9A484F0BF083C918AE5A2C6A3F8157E|glxB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK32660 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATACTGTTTTTCCCTCCTT,  downstream forward: _UP4_TAACCGATTCAGTCGCGTCC
References
24330391

0A244A61A9A484F0BF083C918AE5A2C6A3F8157E

Page visits: 1731

Time of last update: 2024-03-28 11:19:54

Author of last update: Melvin.boenninger