Difference between revisions of "GltC"
(→Expression and regulation) |
(→Extended information on the protein) |
||
| Line 32: | Line 32: | ||
== Extended information on the protein == | == Extended information on the protein == | ||
| − | * '''Kinetic information''' | + | * '''Kinetic information:''' |
| − | * '''Domains''' DNA-binding helix-turn-helix motif: AA 18 ... 37 | + | * '''Domains:''' DNA-binding helix-turn-helix motif: AA 18 ... 37 |
| − | * '''Modification''' | + | * '''Modification:''' |
| − | * '''Effectors of protein activity:'''2-oxoglutarate | + | * '''Effectors of protein activity:''' 2-oxoglutarate |
* '''Interactions:''' | * '''Interactions:''' | ||
** GltC-[[RocG]], This interaction takes place in the presence of glutamate. It prevents the transcription activation of the ''gltAB'' operon. Note that [[RocG]] expression is strongly regulated. <ref>Commichau ''et al''. (2007)</ref> | ** GltC-[[RocG]], This interaction takes place in the presence of glutamate. It prevents the transcription activation of the ''gltAB'' operon. Note that [[RocG]] expression is strongly regulated. <ref>Commichau ''et al''. (2007)</ref> | ||
| − | * '''Localization''' | + | * '''Localization:''' |
== Database entries == | == Database entries == | ||
Revision as of 16:53, 12 December 2008
- Synonyms:
- Description: Transcriptional activator of the gltAB operon. Activates expression of the operon in the absence of arginine.
Contents
The gene
Basic information
- Coordinates:
- Gene length:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry:[2]
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: transcription activation of the gltAB operon
- Protein family: LysR-type transcription regulator
- Paralogous protein(s): none, but there are 19 members of the LysR family in B. subtilis
Extended information on the protein
- Kinetic information:
- Domains: DNA-binding helix-turn-helix motif: AA 18 ... 37
- Modification:
- Effectors of protein activity: 2-oxoglutarate
- Interactions:
- Localization:
Database entries
- Structure
- Swiss prot entry
- KEGG entry
Expression and regulation
- Operon: gltC
- Sigma factor: SigA
- Regulation: autoregulation by GltC
- Regulatory mechanism: autorepression
- Database entries: DBTBS
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- Antibody: available in Stülke lab
Labs working on this gene/protein
Linc Sonenshein, Tufts University, Boston, MA, USA [3]
Jörg Stülke, University of Göttingen, Germany [4]
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. [5]
