Difference between revisions of "GltC"

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(Additional remarks)
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* '''Description:''' Transcriptional activator of the ''gltAB'' operon. Activates expression of the operon in the absence of arginine.
 
* '''Description:''' Transcriptional activator of the ''gltAB'' operon. Activates expression of the operon in the absence of arginine.
 +
 
 
 
=The gene=
 
=The gene=
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* '''Gene length:'''
 
* '''Gene length:'''
 +
 +
==Phenotypes of a mutant ==
  
 
== Database entries ==
 
== Database entries ==
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* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/gltC.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/gltC.html]
  
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10810]
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* '''SubtiList entry:'''[http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10810]
  
 
=The protein=
 
=The protein=
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* '''Paralogous protein(s):''' none, but there are 19 members of the LysR family in ''B. subtilis''
 
* '''Paralogous protein(s):''' none, but there are 19 members of the LysR family in ''B. subtilis''
 
== Database entries ==
 
 
* '''Structure'''
 
 
* '''Swiss prot entry'''
 
 
* '''KEGG entry'''
 
  
 
== Extended information on the protein ==
 
== Extended information on the protein ==
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* '''Localization'''
 
* '''Localization'''
  
=Expression and Regulation=
+
== Database entries ==
 +
 
 +
* '''Structure'''
 +
 
 +
* '''Swiss prot entry'''
 +
 
 +
* '''KEGG entry'''
 +
 
 +
=Expression and regulation=
  
 
* '''Operon:''' ''gltC'' [http://dbtbs.hgc.jp/COG/prom/gltC.html]
 
* '''Operon:''' ''gltC'' [http://dbtbs.hgc.jp/COG/prom/gltC.html]
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* '''Regulatory mechanism:''' autorepression
 
* '''Regulatory mechanism:''' autorepression
  
=Biological Materials =
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=Biological materials =
  
 
* '''Mutant:'''
 
* '''Mutant:'''
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* '''Antibody:''' available in Stülke lab
 
* '''Antibody:''' available in Stülke lab
  
=Phenotypes of a Mutant =
 
  
 
+
=Labs working on this gene/protein=
=Additional remarks=
 
 
 
* '''Labs working on this gene/protein:'''
 
  
 
Linc Sonenshein, Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html]
 
Linc Sonenshein, Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html]
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[[Stülke|Jörg Stülke]], University of Göttingen, Germany
 
[[Stülke|Jörg Stülke]], University of Göttingen, Germany
 
[http://wwwuser.gwdg.de/~genmibio/stuelke.html]
 
[http://wwwuser.gwdg.de/~genmibio/stuelke.html]
 +
 +
=Your additional remarks=
  
 
=References=
 
=References=
 +
 +
# Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID]

Revision as of 16:20, 12 December 2008

  • Synonyms:
  • Description: Transcriptional activator of the gltAB operon. Activates expression of the operon in the absence of arginine.


The gene

Basic information

  • Coordinates:
  • Gene length:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry:[2]

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcription activation of the gltAB operon
  • Protein family: LysR-type transcription regulator
  • Paralogous protein(s): none, but there are 19 members of the LysR family in B. subtilis

Extended information on the protein

  • Kinetic information
  • Domains DNA-binding helix-turn-helix motif: AA 18 ... 37
  • Modification
  • Effectors of protein activity:2-oxoglutarate
  • Interactions:
    • GltC-RocG, This interaction takes place in the presence of glutamate. It prevents the transcription activation of the gltAB operon. Note that RocG expression is strongly regulated. <ref>Commichau et al. (2007)</ref>
  • Localization

Database entries

  • Structure
  • Swiss prot entry
  • KEGG entry

Expression and regulation

  • Operon: gltC [3]
  • Sigma factor: SigA [4]
  • Regulation: autoregulation by GltC [5]
  • Regulatory mechanism: autorepression

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • Antibody: available in Stülke lab


Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA [6]

Jörg Stülke, University of Göttingen, Germany [7]

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. [8]