Difference between revisions of "GlpT"
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** repressed by glucose (6.2-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed] | ** repressed by glucose (6.2-fold) ([[CcpA]]) [http://www.ncbi.nlm.nih.gov/pubmed/12850135 PubMed] | ||
** induced by glycerol ([[GlpP]]) {{PubMed|8012593}} | ** induced by glycerol ([[GlpP]]) {{PubMed|8012593}} | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
Revision as of 14:56, 19 October 2011
- Description: glycerol-3-phosphate permease
| Gene name | glpT |
| Synonyms | ybeE |
| Essential | no |
| Product | glycerol-3-phosphate permease |
| Function | glycerol-3-phosphate uptake |
| MW, pI | 49 kDa, 9.366 |
| Gene length, protein length | 1332 bp, 444 aa |
| Immediate neighbours | glpQ, ybeF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
transporters/ other, utilization of specific carbon sources, utilization of lipids, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU02140
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: SLC37A family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P37948
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- CcpA: transcription repression
- GlpP: transcriptional antitermination via a protein-dependent RNA switch PubMed
- Additional information:
Biological materials
- Mutant: QB5437 (ermC), available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135]
[WorldCat.org]
[DOI]
(P p)
R P Nilsson, L Beijer, B Rutberg
The glpT and glpQ genes of the glycerol regulon in Bacillus subtilis.
Microbiology (Reading): 1994, 140 ( Pt 4);723-30
[PubMed:8012593]
[WorldCat.org]
[DOI]
(P p)
