GgaA

• Description: galactosamine-containing minor teichoic acid biosynthesis
  
  

Gene name	ggaA
Synonyms
Essential	no
Product	unknown
Function	biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: ggaA
Metabolic function and regulation of this protein in SubtiPathways: GgaA
MW, pI	52 kDa, 9.055
Gene length, protein length	1338 bp, 446 aa
Immediate neighbours	ggaB, yvzI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, phosphoproteins

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

• Locus tag: BSU35690

Database entries

• BsubCyc: BSU35690

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: glycosyltransferase 2 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-85 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU35690

• Structure:

• UniProt: P46917

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ggaA-ggaB PubMed

• Expression browser: ggaA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed when phosphate is available (PhoP) PubMed

• Regulatory mechanism:
  • PhoP: transcription repression PubMed

• Additional information:
  • An antisense RNA is predicted for ggaA PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Letal I Salzberg, Eric Botella, Karsten Hokamp, Haike Antelmann, Sandra Maaß, Dörte Becher, David Noone, Kevin M Devine
Genome-wide analysis of phosphorylated PhoP binding to chromosomal DNA reveals several novel features of the PhoPR-mediated phosphate limitation response in Bacillus subtilis.
J Bacteriol: 2015, 197(8);1492-506
[PubMed:25666134] [WorldCat.org] [DOI] (I p)

Alexander K W Elsholz, Kürsad Turgay, Stephan Michalik, Bernd Hessling, Katrin Gronau, Dan Oertel, Ulrike Mäder, Jörg Bernhardt, Dörte Becher, Michael Hecker, Ulf Gerth
Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis.
Proc Natl Acad Sci U S A: 2012, 109(19);7451-6
[PubMed:22517742] [WorldCat.org] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Pierre-Philippe Freymond, Vladimir Lazarevic, Blazenka Soldo, Dimitri Karamata
Poly(glucosyl-N-acetylgalactosamine 1-phosphate), a wall teichoic acid of Bacillus subtilis 168: its biosynthetic pathway and mode of attachment to peptidoglycan.
Microbiology (Reading): 2006, 152(Pt 6);1709-1718
[PubMed:16735734] [WorldCat.org] [DOI] (P p)