GerAC

• Description: nutrient receptor, germination response to L-alanine
  
  

Gene name	gerAC
Synonyms
Essential	no
Product	nutrient receptor
Function	germination response to L-alanine
MW, pI	42 kDa, 7.302
Gene length, protein length	1119 bp, 373 aa
Immediate neighbours	gerAB, liaR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU33070

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: gerABKC lipoprotein family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P07870

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: gerAA-gerAB-gerAC PubMed

• Sigma factor: SigG PubMed, SigF PubMed

• Regulation:
  • expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Venkata Ramana Vepachedu, Peter Setlow
Analysis of interactions between nutrient germinant receptors and SpoVA proteins of Bacillus subtilis spores.
FEMS Microbiol Lett: 2007, 274(1);42-7
[PubMed:17573930] [WorldCat.org] [DOI] (P p)

Krzysztof Hinc, Krzysztofa Nagórska, Adam Iwanicki, Grzegorz Wegrzyn, Simone J Séror, Michal Obuchowski
Expression of genes coding for GerA and GerK spore germination receptors is dependent on the protein phosphatase PrpE.
J Bacteriol: 2006, 188(12);4373-83
[PubMed:16740944] [WorldCat.org] [DOI] (P p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Swaroopa Atluri, Katerina Ragkousi, Donna E Cortezzo, Peter Setlow
Cooperativity between different nutrient receptors in germination of spores of Bacillus subtilis and reduction of this cooperativity by alterations in the GerB receptor.
J Bacteriol: 2006, 188(1);28-36
[PubMed:16352818] [WorldCat.org] [DOI] (P p)

Takao Igarashi, Peter Setlow
Interaction between individual protein components of the GerA and GerB nutrient receptors that trigger germination of Bacillus subtilis spores.
J Bacteriol: 2005, 187(7);2513-8
[PubMed:15774895] [WorldCat.org] [DOI] (P p)

Rosa-Martha Cabrera-Martinez, Federico Tovar-Rojo, Venkata Ramana Vepachedu, Peter Setlow
Effects of overexpression of nutrient receptors on germination of spores of Bacillus subtilis.
J Bacteriol: 2003, 185(8);2457-64
[PubMed:12670969] [WorldCat.org] [DOI] (P p)

I Bagyan, J Hobot, S Cutting
A compartmentalized regulator of developmental gene expression in Bacillus subtilis.
J Bacteriol: 1996, 178(15);4500-7
[PubMed:8755877] [WorldCat.org] [DOI] (P p)

I M Feavers, J Foulkes, B Setlow, D Sun, W Nicholson, P Setlow, A Moir
The regulation of transcription of the gerA spore germination operon of Bacillus subtilis.
Mol Microbiol: 1990, 4(2);275-82
[PubMed:2110996] [WorldCat.org] [DOI] (P p)

A R Zuberi, A Moir, I M Feavers
The nucleotide sequence and gene organization of the gerA spore germination operon of Bacillus subtilis 168.
Gene: 1987, 51(1);1-11
[PubMed:3110007] [WorldCat.org] [DOI] (P p)