GapA

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  • Synonyms:
  • Description: glyceraldehyde-3-phosphate dehydrogenase, (NADH-dependent), glycolytic enzyme

The gene

Basic information

  • Coordinates:
  • Gene length:

Phenotypes of a mutant

essential

Database entries

  • DBTBS entry: [1]
  • SubtiList entry:[2]

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: glyceraldehyde-3-phosphate dehydrogenase, (NADH-dependent)
  • Protein family:
  • Paralogous protein(s): GapB

Extended information on the protein

  • Kinetic information
  • Domains
  • Modification Phosphorylation (STY)
  • Effectors of protein activity:
  • Interactions:
    • GapA-PtsH </br> HPr(Ser-46-P) binds GapA resulting in a slight inhibition of enzymatic activity.
    • GapA-Crh </br> Crh(Ser-46-P) binds GapA resulting in a slight inhibition of enzymatic activity.
  • Localization

membrane and cytoplasm

Database entries

  • Structure
  • Swiss prot entry
  • KEGG entry

Expression and regulation

  • Regulation: CggR represses the operon in the absence of glycolytic sugars
  • Regulatory mechanism: repression

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • Antibody:


Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. [3]