GalE

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  • Description: UDP glucose 4-epimerase

Gene name galE
Synonyms
Essential no
Product UDP glucose 4-epimerase
Function galactose utilization
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 36 kDa, 4.776
Gene length, protein length 1017 bp, 339 aa
Immediate neighbours yxkC, yxkA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GalE context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU38860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-glucose = UDP-galactose (according to Swiss-Prot)
  • Protein family: sugar epimerase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1LRL (from Escherichia coli Y299C mutant, 57% identity, 71% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Blazenka Soldo, Claudio Scotti, Dimitri Karamata, Vladimir Lazarevic
The Bacillus subtilis Gne (GneA, GalE) protein can catalyse UDP-glucose as well as UDP-N-acetylglucosamine 4-epimerisation.
Gene: 2003, 319;65-9
[PubMed:14597172] [WorldCat.org] [DOI] (P p)

O Krispin, R Allmansberger
The Bacillus subtilis galE gene is essential in the presence of glucose and galactose.
J Bacteriol: 1998, 180(8);2265-70
[PubMed:9555917] [WorldCat.org] [DOI] (P p)