Difference between revisions of "GabR"

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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gabR_440025_441464_-1 gabR] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=gabR_440025_441464_-1 gabR] {{PubMed|22383849}}
  
* '''Sigma factor:''' [[SigA]] {{PubMed|12123465}}
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* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12123465}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  

Revision as of 17:15, 16 October 2013

  • Description: transcription activator of gabT-gabD, repressor of gabR

Gene name gabR
Synonyms ycnF
Essential no
Product transcription regulator
Function regulation of gamma-amino butyric acid utilization
Gene expression levels in SubtiExpress: gabR
MW, pI 54 kDa, 6.709
Gene length, protein length 1437 bp, 479 aa
Immediate neighbours yczG, gabT
Sequences Protein DNA DNA_with_flanks
Genetic context
GabR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabR expression.png















Categories containing this gene/protein

utilization of amino acids, transcription factors and their control

This gene is a member of the following regulons

GabR regulon

The GabR regulon:

The gene

Basic information

  • Locus tag: BSU03890

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • transcription activation of the gabT-gabD operon, transcription repression of gabR PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • activation of gabT-gabD expression is triggered by gamma-amino butyrate and pyridoxalphosphate PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • GabR: negative autoregulation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Raji Edayathumangalam, Rui Wu, Roman Garcia, Yuguang Wang, Wei Wang, Cheryl A Kreinbring, Alicia Bach, Jingling Liao, Todd A Stone, Thomas C Terwilliger, Quyen Q Hoang, Boris R Belitsky, Gregory A Petsko, Dagmar Ringe, Dali Liu
Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT.
Proc Natl Acad Sci U S A: 2013, 110(44);17820-5
[PubMed:24127574] [WorldCat.org] [DOI] (I p)

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)