Difference between revisions of "GabR"

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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of gamma-amino butyric acid utilization
 
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of gamma-amino butyric acid utilization
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU03890 gabR]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03890 gabR]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 54 kDa, 6.709   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 54 kDa, 6.709   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yczG]]'', ''[[gabT]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yczG]]'', ''[[gabT]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12197&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03890 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03890 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03890 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:gabR_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:gabR_context.gif]]

Revision as of 12:09, 13 May 2013

  • Description: transcription activator of gabT-gabD, repressor of gabR

Gene name gabR
Synonyms ycnF
Essential no
Product transcription regulator
Function regulation of gamma-amino butyric acid utilization
Gene expression levels in SubtiExpress: gabR
MW, pI 54 kDa, 6.709
Gene length, protein length 1437 bp, 479 aa
Immediate neighbours yczG, gabT
Sequences Protein DNA Advanced_DNA
Genetic context
GabR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabR expression.png
























Categories containing this gene/protein

utilization of amino acids, transcription factors and their control

This gene is a member of the following regulons

GabR regulon

The GabR regulon:

The gene

Basic information

  • Locus tag: BSU03890

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • transcription activation of the gabT-gabD operon, transcription repression of gabR PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • activation of gabT-gabD expression is triggered by gamma-amino butyrate and pyridoxalphosphate PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • GabR: negative autoregulation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)