Difference between revisions of "GabP"

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* '''Description:''' gamma-amino butyric acid permease <br/><br/>
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* '''Description:''' gamma-amino butyric acid permease and minor proline permease<br/><br/>
 
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
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* defective in the utilization of gamma-amino butyrate {{PubMed|24142252}}
  
 
=== Database entries ===
 
=== Database entries ===
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
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** uptake of gamma-amino butyrate {{PubMed|24142252}}
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** minor transporter for proline (allows growth with proline in the absence of the major [[transporters]] [[PutP]] and [[OpuE]]) {{PubMed|24142252}}
  
 
* '''Protein family:''' secondary amino acid transporter
 
* '''Protein family:''' secondary amino acid transporter
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
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** K(M) for gamma-amino butyrate: 77 +/- 17 µM {{PubMed|24142252}}
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** K(M) for proline: 700 +/- 330 µM {{PubMed|24142252}}
  
 
* '''Domains:'''  
 
* '''Domains:'''  

Revision as of 12:16, 28 November 2013

  • Description: gamma-amino butyric acid permease and minor proline permease

Gene name gabP
Synonyms nrg-21
Essential no
Product gamma-amino butyric acid permease
Function utilization of gamma-amino butyric acid
Gene expression levels in SubtiExpress: gabP
Metabolic function and regulation of this protein in SubtiPathways:
Ala, Gly, Ser
MW, pI 50 kDa, 9.45
Gene length, protein length 1407 bp, 469 aa
Immediate neighbours cotA, ydzX
Sequences Protein DNA DNA_with_flanks
Genetic context
GabP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabP expression.png















Categories containing this gene/protein

transporters/ other, utilization of amino acids, membrane proteins

This gene is a member of the following regulons

CodY regulon, TnrA regulon

The gene

Basic information

  • Locus tag: BSU06310

Phenotypes of a mutant

  • defective in the utilization of gamma-amino butyrate PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: secondary amino acid transporter

Extended information on the protein

  • Kinetic information:
    • K(M) for gamma-amino butyrate: 77 +/- 17 µM PubMed
    • K(M) for proline: 700 +/- 330 µM PubMed
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed in the absence of good nitrogen sources (glutamine or ammonium) (TnrA) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References