GabD

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  • Description: succinate-semialdehyde dehydrogenase (NADP), general stress protein

Gene name gabD
Synonyms ycnH
Essential no
Product succinate-semialdehyde dehydrogenase (NADP)
Function utilization of gamma-amino butyric acid
Gene expression levels in SubtiExpress: gabD
MW, pI 50 kDa, 4.763
Gene length, protein length 1386 bp, 462 aa
Immediate neighbours gabT, glcU
Sequences Protein DNA DNA_with_flanks
Genetic context
GabD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabD expression.png
























Categories containing this gene/protein

utilization of amino acids, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

GabR regulon, SigB regulon

The gene

Basic information

  • Locus tag: BSU03910

Phenotypes of a mutant

    • growth defect in the presence of gamma-aminobutyrate PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3RHH (from from Bacillus halodurans C-125 complexed with NADP, 36% identity, 68% similarity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

Your additional remarks

References

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)