Difference between revisions of "GabD"

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|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of gamma-amino butyric acid  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of gamma-amino butyric acid  
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU03910 gabD]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU03910 gabD]
 
|-
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 50 kDa, 4.763   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 50 kDa, 4.763   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gabT]]'', ''[[glcU]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[gabT]]'', ''[[glcU]]''
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12199&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU03910 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU03910 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU03910 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:gabD_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:gabD_context.gif]]

Revision as of 12:09, 13 May 2013

  • Description: succinate-semialdehyde dehydrogenase (NADP), general stress protein

Gene name gabD
Synonyms ycnH
Essential no
Product succinate-semialdehyde dehydrogenase (NADP)
Function utilization of gamma-amino butyric acid
Gene expression levels in SubtiExpress: gabD
MW, pI 50 kDa, 4.763
Gene length, protein length 1386 bp, 462 aa
Immediate neighbours gabT, glcU
Sequences Protein DNA Advanced_DNA
Genetic context
GabD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabD expression.png
























Categories containing this gene/protein

utilization of amino acids, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

GabR regulon, SigB regulon

The gene

Basic information

  • Locus tag: BSU03910

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3RHH (from from Bacillus halodurans C-125 complexed with NADP, 327identity, 68% similarity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)