Difference between revisions of "GabD"

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Revision as of 13:23, 8 August 2012

  • Description: succinate-semialdehyde dehydrogenase (NADP), general stress protein

Gene name gabD
Synonyms ycnH
Essential no
Product succinate-semialdehyde dehydrogenase (NADP)
Function utilization of gamma-amino butyric acid
Gene expression levels in SubtiExpress: gabD
MW, pI 50 kDa, 4.763
Gene length, protein length 1386 bp, 462 aa
Immediate neighbours gabT, glcU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GabD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabD expression.png
























Categories containing this gene/protein

utilization of amino acids, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

GabR regulon, SigB regulon

The gene

Basic information

  • Locus tag: BSU03910

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3RHH (from from Bacillus halodurans C-125 complexed with NADP, 327identity, 68% similarity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)