Fnr

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  • Description: transcriptional regulator of anaerobic genes

Gene name fnr
Synonyms
Essential no
Product transcription regulator (Crp family)
Function regulation of anaerobiosis, fermentation and overflow metabolism
Metabolic function and regulation of this protein in SubtiPathways:
Alternative nitrogen sources
MW, pI 27 kDa, 5.989
Gene length, protein length 714 bp, 238 aa
Immediate neighbours ywiC, narK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Fnr context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

regulators of electron transport, transcription factors and their control

This gene is a member of the following regulons

Fnr regulon, NsrR regulon, ResD regulon

The Fnr regulon

The gene

Basic information

  • Locus tag: BSU37310

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes/ operons controlled by Fnr

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: contains an iron-sulfur cluster

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

The Fnr regulon

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

Other original publications

Ines Gruner, Claudia Frädrich, Lars H Böttger, Alfred X Trautwein, Dieter Jahn, Elisabeth Härtig
Aspartate 141 is the fourth ligand of the oxygen-sensing [4Fe-4S]2+ cluster of Bacillus subtilis transcriptional regulator Fnr.
J Biol Chem: 2011, 286(3);2017-21
[PubMed:21068385] [WorldCat.org] [DOI] (I p)

Michiko M Nakano, Hao Geng, Shunji Nakano, Kazuo Kobayashi
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
J Bacteriol: 2006, 188(16);5878-87
[PubMed:16885456] [WorldCat.org] [DOI] (P p)

M M Nakano, Y Zhu, M Lacelle, X Zhang, F M Hulett
Interaction of ResD with regulatory regions of anaerobically induced genes in Bacillus subtilis.
Mol Microbiol: 2000, 37(5);1198-207
[PubMed:10972836] [WorldCat.org] [DOI] (P p)

M M Nakano, P Zuber, P Glaser, A Danchin, F M Hulett
Two-component regulatory proteins ResD-ResE are required for transcriptional activation of fnr upon oxygen limitation in Bacillus subtilis.
J Bacteriol: 1996, 178(13);3796-802
[PubMed:8682783] [WorldCat.org] [DOI] (P p)

H Cruz Ramos, L Boursier, I Moszer, F Kunst, A Danchin, P Glaser
Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms.
EMBO J: 1995, 14(23);5984-94
[PubMed:8846791] [WorldCat.org] [DOI] (P p)