Difference between revisions of "Fnr"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** repressed unless NO is present under anaerobic conditions ([[NsrR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16885456 PubMed]
 
** expressed under anaerobic conditions ([[Fnr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed]
 
** expressed under anaerobic conditions ([[Fnr]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed]
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[NsrR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16885456 PubMed]
 
** [[Fnr]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed]
 
** [[Fnr]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8846791,16428414 PubMed]
  

Revision as of 16:56, 11 June 2009

  • Description: transcriptional regulator of anaerobic genes

Gene name fnr
Synonyms
Essential no
Product transcription regulator (Crp family)
Function regulation of anaerobiosis, fermentation and overflow metabolism
MW, pI 27 kDa, 5.989
Gene length, protein length 714 bp, 238 aa
Immediate neighbours ywiC, narK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Fnr context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU37310

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes/ operons controlled by Fnr

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed unless NO is present under anaerobic conditions (NsrR) PubMed
    • expressed under anaerobic conditions (Fnr) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)

  1. Reents, H., R. Münch, T. Dammeyer, D. Jahn, and E. Härtig. 2006. The Fnr regulon of Bacillus subtilis. J. Bacteriol. 188: 1103-1112. PubMed
  2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed