fliP

168

part of the flagellar type III export apparatus (flagellar Type III secretion system), part of the CORE complex required for flagellum and nanotube assembly

locus: BSU_16350

Molecular weight: 24.71 kDa

pI: 5.28

Protein length: 221 aa

Gene length: 666 bp

function: flagellum and nanotube assembly

product: part of the type III CORE export apparatus

essential: no

synonyms: fliP

List of homologs in different organisms, belongs to COG1338 (Galperin et al., 2021)

Gene

Coordinates: 1,704,863  1,705,528

Phenotypes of a mutant

• no secretion of [protein|F03144BF8A187C8931938A21433431B8961E8EE7|flgM], permanent inhibition of [protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD] [Pubmed|25313396]
• deficient in both nanotube production and the associated intercellular molecular trafficking [pubmed|30929979]
• defective in [category|SW.4.1.4|Swarming] motility [pubmed|35638827]

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The protein

Protein family

• FliP/MopC/SpaP family (single member, according to UniProt)

Structure

• [PDB|6F2D] (the [protein|6ED6C3DDC4F3142FD01D32840D955B7E4A19F385|fliP]-[protein|A3C07B70C87D671979D053A6272A0FCDED6F3BB7|fliQ]-[protein|9856F25F23264AD1402A85AE9E25F10B68CAD739|fliR] complex of Salmonella typhimurium, 53% identity) [pubmed|29967543]
• [AF|P35528]

[wiki|Localization]

• cell membrane (according to UniProt)
• flagellum basal body (according to UniProt)

Biological materials

Mutant

• BKE16350 ([gene|6ED6C3DDC4F3142FD01D32840D955B7E4A19F385|fliP]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE16350 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GCTTGAACTGAAAATATTTA,  downstream forward: _UP4_AGCTTTTAGGGTAGGTGCTA
• BKK16350 ([gene|6ED6C3DDC4F3142FD01D32840D955B7E4A19F385|fliP]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK16350 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GCTTGAACTGAAAATATTTA,  downstream forward: _UP4_AGCTTTTAGGGTAGGTGCTA

References

Reviews

• 26490009

Original Publications

• 8299954,1597417,17850253,14651647,9657996,8157612,15175317,25313396,24386445,26244495,29967543,30929979,35638827