FhuD

• Description: hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)
  
  

Gene name	fhuD
Synonyms
Essential	no
Product	hydroxamate siderophore ABC transporter (only ferrichrome) (binding protein)
Function	siderophore uptake
Gene expression levels in SubtiExpress: fhuD
Interactions involving this protein in SubtInteract: FhuD
Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis
MW, pI	34 kDa, 9.158
Gene length, protein length	945 bp, 315 aa
Immediate neighbours	fhuB, yvsH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, acquisition of iron, iron metabolism

This gene is a member of the following regulons

Fur regulon

The gene

Basic information

• Locus tag: BSU33320

Phenotypes of a mutant

• poor growth with the xenosiderophore ferrichrome as single source of iron PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 8 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • FhuC-(FhuB-FhuG)-(FhuD-YxeB) PubMed

• Localization: cell membrane (according to Swiss-Prot), extracellular (signal peptide) PubMed

Database entries

• Structure:

• UniProt: P37580

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: fhuD (according to DBTBS)

• Expression browser: fhuD PubMed

• Sigma factor:

• Regulation:
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: