fbp

168

fructose-1,6-bisphosphatase, involved in gluconeogenesis

locus: BSU_40190

Molecular weight: 77.80 kDa

pI: 5.6

Protein length: 671 aa

Gene length: 2016 bp

function: gluconeogenesis

product: fructose-1,6-bisphosphatase

essential: no

ec: 3.1.3.11

synonyms: fbp, fdp, yydE

List of homologs in different organisms, belongs to COG3855 (Galperin et al., 2021)

Gene

Coordinates: 4,128,029  4,130,044

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The protein

Catalyzed reaction/ biological activity

• β-D-fructose 1,6-bisphosphate + H₂O --> β-D-fructose 6-phosphate + phosphate (according to UniProt)

Protein family

• FBPase class 3 family (single member, according to UniProt)

Structure

• [AF|Q45597]

Biological materials

Mutant

• MGNA-B811 (yydE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1810 NBRP B. subtilis, Japan]
• BKE40190 ([gene|79DD9B2E2EBB4646327AFC2148CE040823DE89D3|fbp]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE40190 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAAACCGTCCATCCCCTTT,  downstream forward: _UP4_TGAGGGGTGTGGGGTTCAGG
• BKK40190 ([gene|79DD9B2E2EBB4646327AFC2148CE040823DE89D3|fbp]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK40190 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAAACCGTCCATCCCCTTT,  downstream forward: _UP4_TGAGGGGTGTGGGGTTCAGG

References

• 36815589,6257649,221467,9696785,24571712