Difference between revisions of "FadB"
| Line 107: | Line 107: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
** induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}} | ** induced by long-chain fatty acids ([[FadR]]) {{PubMed|17189250}} | ||
| − | ** | + | ** subject to carbon catabolite repression (3.8-fold) ([[CcpA]]-[[PtsH|HPr(Ser-P)]] {{PubMed|12850135,21398533}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
** [[FadR]]: transcription repression {{PubMed|17189250}} | ** [[FadR]]: transcription repression {{PubMed|17189250}} | ||
| − | ** | + | ** [[CcpA]]-[[PtsH|HPr(Ser-P)]]: transcription repression {{PubMed|21398533}} |
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 134: | Line 134: | ||
=References= | =References= | ||
| − | + | '''Additional publications:''' {{PubMed|21398533}} | |
<pubmed>12850135, 17189250, 17919287</pubmed> | <pubmed>12850135, 17189250, 17919287</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 12:51, 19 March 2011
- Description: 3-hydroxyacyl-CoA dehydratase
| Gene name | fadB |
| Synonyms | ysiB |
| Essential | no |
| Product | 3-hydroxyacyl-CoA dehydratase |
| Function | fatty acid degradation |
| Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation | |
| MW, pI | 27 kDa, 4.951 |
| Gene length, protein length | 774 bp, 258 aa |
| Immediate neighbours | etfB, fadR |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28540
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O (according to Swiss-Prot)
- Protein family: enoyl-CoA hydratase/isomerase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 3PEA (from B. anthracis, 49% identity, 66% similarity)
- UniProt: P94549
- KEGG entry: [3]
- E.C. number: 4.2.1.17
Additional information
Expression and regulation
- Regulation:
- induced by long-chain fatty acids (FadR) PubMed
- subject to carbon catabolite repression (3.8-fold) (CcpA-HPr(Ser-P) PubMed
- Regulatory mechanism:
- FadR: transcription repression PubMed
- CcpA-HPr(Ser-P): transcription repression PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287]
[WorldCat.org]
[DOI]
(P p)
Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250]
[WorldCat.org]
[DOI]
(P p)
Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135]
[WorldCat.org]
[DOI]
(P p)
