FadA

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  • Description: acetyl-CoA C-acyltransferase

Gene name fadA
Synonyms yusK
Essential no
Product acetyl-CoA C-acyltransferase
Function fatty acid degradation
Gene expression levels in SubtiExpress: fadA
Metabolic function and regulation of this protein in SubtiPathways:
fadA
MW, pI 40 kDa, 5.184
Gene length, protein length 1173 bp, 391 aa
Immediate neighbours fadE, fadN
Sequences Protein DNA DNA_with_flanks
Genetic context
YusK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FadA expression.png




























Categories containing this gene/protein

utilization of lipids, sporulation/ other

This gene is a member of the following regulons

CcpA regulon, FadR regulon, SdpR regulon

The gene

Basic information

  • Locus tag: BSU32830

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (according to Swiss-Prot)
  • Protein family: thiolase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3SS6 (the protein of B. anthracis, 41% identity, 73% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 37 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)

Hiroshi Matsuoka, Kazutake Hirooka, Yasutaro Fujita
Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation.
J Biol Chem: 2007, 282(8);5180-94
[PubMed:17189250] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)