fabD

168

malonyl CoA-acyl carrier protein transacylase

locus: BSU_15900

Molecular weight: 33.88 kDa

pI: 4.51

Protein length: 317 aa

Gene length: 954 bp

function: fatty acid biosynthesis

product: malonyl CoA-acyl carrier protein transacylase

essential: yes

ec: 2.3.1.39

synonyms: fabD, ylpE

List of homologs in different organisms, belongs to COG0331 (Galperin et al., 2021)

Gene

Coordinates: 1,663,567 → 1,664,520

Phenotypes of a mutant

• essential [Pubmed|12682299]
• enhanced colony wrinkling upon knockdown [pubmed|36069446]

Advertisement

The protein

Catalyzed reaction/ biological activity

• holo-[ACP] + malonyl-CoA --> CoA + malonyl-[ACP] (according to UniProt)

Protein family

• fabD family (with [protein|55C821F68B2E5F9F45CC2B2C9494D48D5C33266A|pksC] and [protein|CB0B856B22984DD5B10F01DD07C3961FAA742923|pksE], according to UniProt)

Structure

• [PDB|1MLA] (the enzyme from ''E. coli'') [Pubmed|7768883]
• [AF|P71019]

References

Reviews

• 15952903

Original Publications

• 12737802,16932747,19850612,7768883,16091051,36069446