ebrA

168

multidrug efflux transporter

locus: BSU_17300

Molecular weight: 11.21 kDa

pI: 9.37

Protein length: 105 aa

Gene length: 318 bp

function: multidrug resistance

product: multidrug efflux transporter

essential: no

synonyms: ebrA

List of homologs in different organisms, belongs to COG2076 (Galperin et al., 2021)

Gene

Coordinates: 1,865,058  1,865,375

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The protein

Protein family

• paired small multidrug resistance  protein family ([wiki|PSMR family]) [Pubmed|17942072]
• [wiki|drug/metabolite transporter (DMT) superfamily] (according to UniProt)
• [wiki|Small multidrug resistance (SMR) (TC 2.A.7.1) family] (according to UniProt)

Structure

• [PDB|6D0S] (human protein, 23% identity)

Paralogous protein(s)

• [protein|74668FF19D097722D523CC54288B6409DE267631|ebrB]

[wiki|Localization]

• cell membrane [Pubmed|17417881]

Biological materials

Mutant

• BKE17300 ([gene|53576746FF1B644A1980F8ACD0E8F4A54CDDAD83|ebrA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE17300 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCATGAATTCTCCTCACT,  downstream forward: _UP4_AATTGGCCGTAAAGGAGTGA
• BKK17300 ([gene|53576746FF1B644A1980F8ACD0E8F4A54CDDAD83|ebrA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK17300 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCATGAATTCTCCTCACT,  downstream forward: _UP4_AATTGGCCGTAAAGGAGTGA

References

Reviews

• 17942072

Original Publications

• 17417881