Difference between revisions of "ECF transporter"

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== The general components of the ECF transporters ==
 
== The general components of the ECF transporters ==
 
* [[ybxA]] ATP-binding A1 protein (EcfA1)
 
* [[ybxA]] ATP-binding A1 protein (EcfA1)
 +
* [[ybaE]] ATP-binding A2 protein (EcfA2)
 +
* [[ybaF]] membrane-spanning T protein (EcfT)
  
 
== The substrate-specific S components of the ECF transporters ==
 
== The substrate-specific S components of the ECF transporters ==
 +
* [[RibU]]: uptake of riboflavin
 +
* [[ThiT]]: uptake of thiamine
 +
* [[YhfU]]: uptake of biotin
 +
* [[TrpP]]: uptake of tryptophan
  
 
== Important reviews and publications ==
 
== Important reviews and publications ==
 
<pubmed>23584589 , 21135102, 20497229, </pubmed>
 
<pubmed>23584589 , 21135102, 20497229, </pubmed>

Revision as of 15:07, 13 July 2013

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transport proteins


ECF transporters are required for the uptake of micronutrients such as cofactors (vitamins), metal ions, or amino acids. The transporters are composed of three general components (membrane spanning T protein und two ATP-hydrolyzing A proteins) and substrate-specific S proteins. In B. subtilis, there are four known substrates for ECF transporters, riboflavin, thiamine, biotin, and tryptophan.

The general components of the ECF transporters

  • ybxA ATP-binding A1 protein (EcfA1)
  • ybaE ATP-binding A2 protein (EcfA2)
  • ybaF membrane-spanning T protein (EcfT)

The substrate-specific S components of the ECF transporters

  • RibU: uptake of riboflavin
  • ThiT: uptake of thiamine
  • YhfU: uptake of biotin
  • TrpP: uptake of tryptophan

Important reviews and publications

Ke Xu, Minhua Zhang, Qin Zhao, Fang Yu, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding, Peng Zhang
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis.
Nature: 2013, 497(7448);268-71
[PubMed:23584589] [WorldCat.org] [DOI] (I p)

Josy ter Beek, Ria H Duurkens, Guus B Erkens, Dirk Jan Slotboom
Quaternary structure and functional unit of energy coupling factor (ECF)-type transporters.
J Biol Chem: 2011, 286(7);5471-5
[PubMed:21135102] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)