Difference between revisions of "DynA"

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* '''Description:''' unknown <br/><br/>
+
* '''Description:''' dynamin-like protein, mediates membrane fusion<br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
+
|style="background:#ABCDEF;" align="center"| '''Product''' || dynamin-like protein
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || unknown
+
|style="background:#ABCDEF;" align="center"|'''Function''' || fusion of membranes
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 137 kDa, 5.724   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 137 kDa, 5.724   
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:'''  
+
* '''Catalyzed reaction/ biological activity:''' mediates nucleotide independent membrane fusion ''in vitro'' {{PubMed|21205012}}
 +
 
  
 
* '''Protein family:''' gerABKA family (according to Swiss-Prot)
 
* '''Protein family:''' gerABKA family (according to Swiss-Prot)
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* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''Domains:''' two separate dynamin-like subunits and GTPase domains {{PubMed|21205012}}
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''Cofactor(s):''' Mg(2+) {{PubMed|21205012}}
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
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=References=
 
=References=
<pubmed> 8396117</pubmed>
+
<pubmed> 8396117 21205012 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 13:27, 6 January 2011

  • Description: dynamin-like protein, mediates membrane fusion

Gene name dynA
Synonyms ypbR
Essential no
Product dynamin-like protein
Function fusion of membranes
MW, pI 137 kDa, 5.724
Gene length, protein length 3579 bp, 1193 aa
Immediate neighbours ypbS, fbpC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YpbR context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

proteins of unknown function

This gene is a member of the following regulons

Fur regulon

The gene

Basic information

  • Locus tag: BSU22030

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: mediates nucleotide independent membrane fusion in vitro PubMed


  • Protein family: gerABKA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two separate dynamin-like subunits and GTPase domains PubMed
  • Modification:
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed in the presence of iron (Fur) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Frank Bürmann, Nina Ebert, Suey van Baarle, Marc Bramkamp
A bacterial dynamin-like protein mediating nucleotide-independent membrane fusion.
Mol Microbiol: 2011, 79(5);1294-304
[PubMed:21205012] [WorldCat.org] [DOI] (I p)

L Chen, L P James, J D Helmann
Metalloregulation in Bacillus subtilis: isolation and characterization of two genes differentially repressed by metal ions.
J Bacteriol: 1993, 175(17);5428-37
[PubMed:8396117] [WorldCat.org] [DOI] (P p)