DltA

From SubtiWiki
Revision as of 13:53, 31 October 2012 by Jstuelk (talk | contribs)
Jump to: navigation, search
  • Description: D-alanyl-D-alanine carrier protein ligase, alanylation of phosphatidylglycerol provides some resistance against positively charged antimicrobial peptides

Gene name dltA
Synonyms ipa-5r, dae
Essential no
Product D-alanyl-D-alanine carrier protein ligase
Function biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: dltA
MW, pI 55 kDa, 4.929
Gene length, protein length 1509 bp, 503 aa
Immediate neighbours menA, dltB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
DltA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DltA expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigD regulon, SigM regulon, SigX regulon, Spo0A regulon, stringent response, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU38500

Phenotypes of a mutant

    • increased sensitivity to lysozyme PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate) (according to Swiss-Prot)
  • Protein family: DltA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • expression is reduced in a SigV mutant PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References

Additional publications: PubMed