dfrA

dfrA
168

dihydrofolate reductase

locus
BSU_21810
Molecular weight
19.03 kDa
pI
5.22
Protein length
Gene length
function
biosynthesis of folate
product
dihydrofolate reductase
essential
yes
ec
1.5.1.3
synonyms
dfrA, tmp

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0262 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,296,603 → 2,297,109
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
(6S)-5,6,7,8-tetrahydrofolate + NADP+ --> 7,8-dihydrofolate + H+ + NADPH (according to UniProt)
Protein family
dihydrofolate reductase family (single member, according to UniProt)
[wiki|Domains]
DHFR domain (aa 1-159) (according to UniProt)
Structure
[PDB|8UVZ] (complex with NADP+ and folate) [pubmed|37986818]
[PDB|1ZDR] (Geobacillus stearothermophilus)
[AF|P11045]
Expression and Regulation
Operons
genes
[gene|8B515C789439354F870023E69077D2C1D709E046|ypjP]-[gene|2CB3BAF17F59A858D249619A436EF660CAA58DD5|ypjQ]-[gene|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]-[gene|B740E971204AC14BA456B8C93A86D4BDC29524FF|dfrA]-[gene|9D1DAA5E69DD12FDE0FB33EA0863E0CB214120EC|ypkP]
description
[Pubmed|22383849]
Open in new tab

[gene|8B515C789439354F870023E69077D2C1D709E046|ypjP]→[gene|9D1DAA5E69DD12FDE0FB33EA0863E0CB214120EC|ypkP]

2024-03-14 08:48:01

Jstuelk

72

235b0d972d347f04b87f4c45ebac71a8a9d4b96a

9EB04D4A3A7698B00A36018A9A11CB02D30C8250

genes
[gene|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]-[gene|B740E971204AC14BA456B8C93A86D4BDC29524FF|dfrA]
description
[Pubmed|2840350]
regulation
weak induction in the presence of glucose ([protein|search|CcpN]) [Pubmed|19732150]
regulatory mechanism
[protein|2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|ccpN]: activation, weak, in [regulon|protein:2234D81F8F9B92EAF1CF6F73BEC92D4DE54E2636|ccpN regulon]
Open in new tab

[gene|9F9643D51E9ABA537892B19312491697CECDDCCF|thyB]→[gene|B740E971204AC14BA456B8C93A86D4BDC29524FF|dfrA]

2024-02-23 04:22:31

ghost

46

c85a29ba6a879af8f10ee961ab515c0e0a8b2658

B9BDE226BFA3A6A21A7E3540C80A424429DFA9B3

References
2840350,6436144,3918568,24158440,37986818

B740E971204AC14BA456B8C93A86D4BDC29524FF

Page visits: 2793

Time of last update: 2024-03-28 14:50:03

Author of last update: Jstuelk