deoR

deoR
168

transcriptional repressor of the [gene|81CD1F97E887549F7FB742FCEF38B86B84383F5D|dra]-[gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]-[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp] operon

locus
BSU_39430
Molecular weight
35.10 kDa
pI
6
Protein length
Gene length
function
regulation of deoxyribonucleotide utilization
product
transcriptional repressor
essential
no
synonyms
deoR, yxxC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2390 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,052,379 → 4,053,320
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The protein
Catalyzed reaction/ biological activity
transcription repression of the [gene|81CD1F97E887549F7FB742FCEF38B86B84383F5D|dra]-[gene|4F718681A7AD0C86B2551248570F493AC0B2E7E9|nupC]-[gene|D2EB7BBAC8817912DAC4E215879F5A4E2C47ECAF|pdp] operon
Protein family
SorC transcriptional regulatory family (with [protein|ADA6F2EDC7B18FDFFA47CC8C55BCDDE1B6821160|cggR], according to UniProt)
[wiki|Domains]
N-terminal DNA-binding domain [Pubmed|24863636]
C-terminal effector binding domain [Pubmed|24863636]
Structure
[PDB|4OQQ] (C-terminal effector binding domain) [Pubmed|24863636]
[PDB|7BHY] (complex of the DNA-binding domain with the operator DNA) [pubmed|34726169]
[http://pdb.org/pdb/explore/explore.do?structureId=4OQP 4OQP] (C-terminal effector binding domain bound to the effector deoxyribose-5-phosphate ) [Pubmed|24863636]
[AF|P39140]
Effectors of protein activity
deoxyribose-5-phosphate  acts as the molecular inducer [Pubmed|24863636]
Expression and Regulation
Operons
genes
[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]
description
[Pubmed|10746760]
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[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]

2024-03-14 22:16:29

ghost

57

0329b698241387249c8094455fc2617143f3f14b

6AC95F79C557792B4D2CB6DE2804F1FAFF574521

Biological materials
Mutant
BKE39430 (Δ[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE39430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCTGCACCTCCCTGTGG,  downstream forward: _UP4_TGACACGTTCAAACCTTTCA
BKK39430 (Δ[gene|E9C4C569F18B3335DA9C7FB5B17C87D661E62669|deoR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK39430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCTGCACCTCCCTGTGG,  downstream forward: _UP4_TGACACGTTCAAACCTTTCA
References
10714997,8550462,10074062,24863636,34726169

E9C4C569F18B3335DA9C7FB5B17C87D661E62669

Page visits: 3879

Time of last update: 2024-03-28 07:26:59

Author of last update: Jstuelk