DegR

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  • Description: regulation of degradative enzyme production

Gene name degR
Synonyms prtR
Essential no
Product positive effector of DegU-phosphate stability
Function control of DegU activity
Gene expression levels in SubtiExpress: degR
MW, pI 6 kDa, 5.158
Gene length, protein length 180 bp, 60 aa
Immediate neighbours cspD, ypzA
Sequences Protein DNA Advanced_DNA
Genetic context
DegR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DegR expression.png
























Categories containing this gene/protein

transcription factors and their control

This gene is a member of the following regulons

SigD regulon

The gene

Basic information

  • Locus tag: BSU21940

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

M Ogura, Y Ohshiro, S Hirao, T Tanaka
A new Bacillus subtilis gene, med, encodes a positive regulator of comK.
J Bacteriol: 1997, 179(20);6244-53
[PubMed:9335269] [WorldCat.org] [DOI] (P p)

M Ogura, T Tanaka
Bacillus subtilis ComK negatively regulates degR gene expression.
Mol Gen Genet: 1997, 254(2);157-65
[PubMed:9108277] [WorldCat.org] [DOI] (P p)

M Ogura, T Tanaka
Transcription of Bacillus subtilis degR is sigma D dependent and suppressed by multicopy proB through sigma D.
J Bacteriol: 1996, 178(1);216-22
[PubMed:8550420] [WorldCat.org] [DOI] (P p)

K Mukai, M Kawata-Mukai, T Tanaka
Stabilization of phosphorylated Bacillus subtilis DegU by DegR.
J Bacteriol: 1992, 174(24);7954-62
[PubMed:1459944] [WorldCat.org] [DOI] (P p)

M Yang, H Shimotsu, E Ferrari, D J Henner
Characterization and mapping of the Bacillus subtilis prtR gene.
J Bacteriol: 1987, 169(1);434-7
[PubMed:3098734] [WorldCat.org] [DOI] (P p)

Y Nagami, T Tanaka
Molecular cloning and nucleotide sequence of a DNA fragment from Bacillus natto that enhances production of extracellular proteases and levansucrase in Bacillus subtilis.
J Bacteriol: 1986, 166(1);20-8
[PubMed:3082853] [WorldCat.org] [DOI] (P p)