dck

dck
168

deoxyadenosin/deoxycytidine kinase

locus
BSU_00140
Molecular weight
25.30 kDa
pI
5.54
Protein length
Gene length
function
purine salvage and interconversion
product
deoxyadenosin/deoxycytidine kinase
essential
no
synonyms
dck, yaaF

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1428 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
22,496 → 23,149
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The protein
Catalyzed reaction/ biological activity
ATP + deoxyadenosine --> ADP + dAMP (accoding to UniProt)
NTP + deoxycytidine --> NDP + dCMP (accoding to UniProt)
Protein family
DCK/DGK family (together woth [protein|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]) (accoding to UniProt)
Structure
[PDB|2JAQ] (DAK from Mycoplasma mycoides, 35% identity) [pubmed|17229440]
[AF|P37529]
Paralogous protein(s)
[protein|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]
[wiki|Localization]
cytoplasm (accoding to UniProt)
Expression and Regulation
Operons
genes
[gene|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]-[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]
description
[pubmed|22383849]
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[gene|0DA340B3D23B63C6BD284BF86409558A31B12B53|dgk]→[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]

2024-02-29 10:38:02

Jstuelk

52

a79e3573c7ef40ce7edc240f2c862e5e075bc687

5B80CB1DA13607F688D45E84AA89AAB4A93774D1

Biological materials
Mutant
MGNA-B887 (yaaF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1886 NBRP B. subtilis, Japan]
BKE00140 (Δ[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE00140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATTCTTAGGGATATGATGTT,  downstream forward: _UP4_TGAATCTCAGTCGAGATTCA
BKK00140 (Δ[gene|D749382783437F40AE1C66755F57D44E3FCA193F|dck]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK00140 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATTCTTAGGGATATGATGTT,  downstream forward: _UP4_TGAATCTCAGTCGAGATTCA
References
6251049,11078735,17229440

D749382783437F40AE1C66755F57D44E3FCA193F

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Time of last update: 2024-03-28 15:19:24

Author of last update: Jstuelk