dapG

168

aspartokinase I (alpha and beta subunits)

locus: BSU_16760

Molecular weight: 42.82 kDa

pI: 5.71

Protein length: 404 aa

Gene length: 1215 bp

function: biosynthesis of lysine and peptidoglycan

product: aspartokinase I (alpha and beta subunits)

essential: yes

ec: 2.7.2.4

synonyms: dapG, lssD

List of homologs in different organisms, belongs to COG0527 (Galperin et al., 2021)

Gene

Coordinates: 1,747,123  1,748,337

Phenotypes of a mutant

• essential [Pubmed|28189581]

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The protein

Catalyzed reaction/ biological activity

• ATP + L-aspartate --> 4-phospho-L-aspartate + ADP (according to UniProt)

Protein family

• aspartokinase family (with [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC] and [protein|548E92526BC00999031D6EDE43FE061CE0448AFC|thrD], according to UniProt)

[wiki|Domains]

• [wiki|ACT domain] (aa 344-404) (according to UniProt)

Structure

• [PDB|1SFT] (from ''Geobacillus stearothermophilus'', 57% identity) [Pubmed|9063881]
• [AF|Q04795]

Effectors of protein activity

• inhibited by diaminopimelic acid [Pubmed|2152900]

Paralogous protein(s)

• [protein|F7B947938FB40E54D89A719E9610C5A4AA400674|lysC]

References

Reviews

• 19946135,22079167

Original Publications

• 8345520,2153658,15699190,8098035,2152900,9063881,28189581