dapF

168

diaminopimelate epimerase

locus: BSU_32170

Molecular weight: 30.72 kDa

pI: 4.51

Protein length: 284 aa

Gene length: 855 bp

function: biosynthesis of lysine and peptidoglycan

product: diaminopimelate epimerase

essential: yes

ec: 5.1.1.7

synonyms: dapF, yutL

List of homologs in different organisms, belongs to COG0253 (Galperin et al., 2021)

Gene

Coordinates: 3,306,040  3,306,894

Phenotypes of a mutant

• essential [Pubmed|12682299]

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The protein

Catalyzed reaction/ biological activity

• LL-2,6-diaminoheptanedioate --> meso-2,6-diaminopimelate (according to UniProt)

Protein family

• diaminopimelate epimerase family (single member, according to UniProt)

Structure

• [PDB|2OTN] (from ''Bacillus anthracis str. ames'', 62% identity, 75% similarity)
• [AF|O32114]

[wiki|Localization]

• cytoplasm (according to Swiss-Prot)

Biological materials

Mutant

• MGNA-B574 (yutL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1573 NBRP B. subtilis, Japan]