DapA

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  • Description: dihydrodipicolinate synthase <br/><br/>
Gene name dapA
Synonyms
Essential yes PubMed
Product dihydrodipicolinate synthase
Function biosynthesis of lysine and peptidoglycan
Metabolic function and regulation of this protein in SubtiPathways: <br/>Lys, Thr
MW, pI 30 kDa, 4.928
Gene length, protein length 870 bp, 290 aa
Immediate neighbours dapG, rnjB
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> DapA context.gif
<div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

  • Locus tag: BSU16770

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H<sub>2</sub>O (according to Swiss-Prot)
  • Protein family: DHDPS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 3CPR (from Corynebacterium glutamicum, 39% identity, 58% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

<pubmed>8345520,,15699190 8098035,, </pubmed>