CysL

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  • Description: transcriptional activator of the cysJ-cysI operon

Gene name cysL
Synonyms ywfK, ipa-89d
Essential no
Product transcriptional regulator (LysR family)
Function regulation of cysteine biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Cys, Met & Sulfate assimilation
MW, pI 34 kDa, 6.963
Gene length, protein length 897 bp, 299 aa
Immediate neighbours ywfL, pta
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwfK context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

sulfur metabolism, transcription factors and their control

This gene is a member of the following regulons

CysL regulon

The CysL regulon:

The gene

Basic information

  • Locus tag: BSU37650

Phenotypes of a mutant

  • unable to grow with sulfate or sulfite as the only sulfur source PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by sulfate, sulfite, and thiosulfate (CysL) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Isabelle Guillouard, Sandrine Auger, Marie-Françoise Hullo, Farid Chetouani, Antoine Danchin, Isabelle Martin-Verstraete
Identification of Bacillus subtilis CysL, a regulator of the cysJI operon, which encodes sulfite reductase.
J Bacteriol: 2002, 184(17);4681-9
[PubMed:12169591] [WorldCat.org] [DOI] (P p)