CypX

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Gene name cypX
Synonyms
Essential no
Product cytochrome P450, cyclo-l-leucyl-l-leucyl dipeptide oxidase
Function biosynthesis of the extracellular iron chelate pulcherrimin
MW, pI 45 kDa, 5.306
Gene length, protein length 1215 bp, 405 aa
Immediate neighbours yvnA, yvmC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CypX context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CypX expression.png
























Categories containing this gene/protein

acquisition of iron, electron transport/ other, iron metabolism

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

  • Locus tag: BSU35060

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • implicated in the three-step oxidative transformation of the diketopiperazine cyclo-l-leucyl-l-leucyl into pulcherriminic acid PubMed
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Max J Cryle, Stephen G Bell, Ilme Schlichting
Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry: 2010, 49(34);7282-96
[PubMed:20690619] [WorldCat.org] [DOI] (I p)

R L Uffen, E Canale-Parola
Synthesis of pulcherriminic acid by Bacillus subtilis.
J Bacteriol: 1972, 111(1);86-93
[PubMed:4204912] [WorldCat.org] [DOI] (P p)

additional paper